The John Insall Award: A Minimum 10-year Outcome Study of Autologous Chondrocyte Implantation

Autologous Chondrocyte Implantation

Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study.

Autologous chondrocyte implantation (ACI) is used widely as a treatment for symptomatic chondral and osteochondral defects of the knee. Variations of the original periosteum-cover technique include the use of porcine-derived type I/type III collagen as a cover (ACI-C) and matrix-induced autologous chondrocyte implantation (MACI) using a collagen bilayer seeded with chondrocytes. We have perform...

A Randomized Trial Comparing Autologous Chondrocyte Implantation

Does smoking influence outcome after autologous chondrocyte implantation?: A case-controlled study.

Smoking is known to have an adverse effect on wound healing and musculoskeletal conditions. This case-controlled study looked at whether smoking has a deleterious effect in the outcome of autologous chondrocyte implantation for the treatment of full thickness chondral defects of the knee. The mean Modified Cincinatti Knee score was statistically significantly lower in smokers (n = 48) than in n...

Autologous chondrocyte implantation in the adolescent knee.

BACKGROUND Autologous chondrocyte implantation (ACI) has been shown to have favorable results in the treatment of symptomatic chondral and osteochondral lesions. However, there are few reports on the outcomes of this technique in adolescents. PURPOSE The aim of this study was to assess pain relief and functional outcome in adolescents undergoing ACI. STUDY DESIGN Case series; Level of evide...